Impaired B Cell Function in Mice Lacking Perforin-2

Perforin-2 (P2) is a pore-forming protein with cytotoxic activity against intracellular bacterial pathogens.P2 knockout (P2KO) mice are unable to control infections and die from normally non-lethal bacterial infections.Here we show that P2KO mice as compared to WT mice show significantly higher levels of systemic inflammation, measured by inflammat

read more